THE UBIQUITIN-SPECIFIC PROTEASE 8 ANTAGONIZES MELATONIN-INDUCED ENDOCYTIC DEGRADATION OF MT1 RECEPTOR TO PROMOTE LUNG ADENOCARCINOMA GROWTH

Introduction: The human genome encodes two melatonin receptors (MT1 and MT2) that relay melatonin signals to cellular interior.Accumulating evidence has linked melatonin to multiple health benefits, among which its anticancer effects have become well-established.However, the implications of its receptors in lung adenocarcinoma have so far remained